If you are over 30 years old and have only had to choose a dietary supplement in the past, it is advisable to consider liposomal glutathione. Glutathione is one of the best universal supplements for managing the biochemical stress of life, and its liposomal form (or in some cases the S-acetyl form) is the most bioavailable because it allows the body to absorb what you take.
The reason glutathione should be the first choice is that it is the most important natural antioxidant in the body. Glutathione, often referred to as primary detoxifier, is responsible for the excretion of various metal toxins such as mercury, various fungal toxins from pesticides, herbicides, petrochemicals and alcohol metabolites.
Your immune system depends onglutathione If you rely on the glutathione we all use as we get older (see below), you will lose the ability to fight effectively against infections, oxidative stress, chronic inflammation and much more, about which I will tell you in a moment.
Glutathione is your main nutrient
It consists of three amino acids: L-Glutamine, L-Cysteine and L-Glycine, glutathione is a sulfur-containing molecule of an antioxidant and nutrient produced in each cell of the human body. It is found in higher concentrations in the liver, eyes, spleen, pancreas and kidneys, while it is mainly used in the brain and liver to capture oxidants responsible for cell damage and inflammation.
Glutathione is the only protective antioxidant produced by and is therefore the most important because it protects cells from oxidative stress caused by free radicals. It protects sensitive DNA from damage, while helping to bind heavy metals, remove toxins and strengthen immune function; it is also particularly useful in viral infections, as you will see when I turn to the S-acetyl form of glutathione.  
Glutathione is mainly used in the brain and liver to capture oxidants responsible for cell damage and inflammation. It is useful for the support of the brain and neurological functions and for the detoxification and elimination of certain heavy metals.
If you often experience symptoms of brain fog, memory and/or concentration problems, a glutathione preparation is sufficient. In the same way, inflammatory diseases, including arthritis and asthma, react well to glutathione. As an antioxidant, this treatment is beneficial for general health and disease prevention.
Glutathione has many important functions:
- Making DNA, the building blocks of proteins and cells.
- Supporting immune function
- By destroying a few free radicals
- Support of certain enzyme functions
- Regenerate vitamins C and E
- Removal of mercury from the brain
- Liver and gall bladder support in fat management.
- Promotion of regular cell death (a process known as apoptosis).
As I wrote in our liver detox blog post:
Of these [detoxifying] nutrients, glutathione is the most important. Glutathione is so important that it is known as the most important antioxidant. Glutathione is the most common antioxidant in the body and can be regenerated in the liver, but food sources of glutathione are poorly absorbed by the body. Although it is very important to consume foods rich in glutathione such as asparagus, avocados, spinach and broccoli, some additives may inhibit the detoxification 1A.9 The use of glutathione in foods is also important.
Watch the unstoppable founder of Quicksilver Scientific, Dr. Christopher Shade, explain in two minutes why glutathione is the flagship of Quicksilver Scientific.
Unfortunately, our body’s capacity for glutathione decreases at the age of. Chronic disease and prolonged toxic exposure can not only break down glutathione but also inhibit its production. To correct its depletion, you need an additive that can be optimised by different forms of glutathione according to your needs and preferences. I’ll tell you more about this later, but first let’s talk about why your body needs glutathione, especially at an advanced age.
7 reasons why you wantGlutathione
Although glutathione is the body’s main antioxidant and detoxifier, this attribution is not able to treat a wide range of diseases that glutathione can improve. Clinically, glutathione plays an important role in the treatment of diseases ranging from mental health to viral infections and heavy metal detoxification.
Here are seven major health benefits of adding glutathione.
1. Reduces mercury and cellular toxicity
Glutathione is essential for cell detoxification. The detoxification process in Phase II binds toxins to substances such as glutathione to form larger, inactive, water-soluble molecules. Toxins such as mercury bind to glutathione, are removed from the stools of the cell, bile and body. Glutathione is therefore necessary both to protect the cell’s sensitive chemical equipment and to eliminate toxins. Because glutathione is used to remove mercury and other toxins from the cell, it can be depleted under toxic conditions. 
2. Reduces oxidative stress
Oxidative stress occurs when there is an imbalance between the production of free radicals and the body’s ability to neutralize them. Increased oxidative stress can be a warning for many diseases, including diabetes, cancer and rheumatoid arthritis. Glutathione helps prevent exposure to oxidative stress, which can reduce the incidence of free radical damage.
An article in Cancer Science and Therapy states that glutathione deficiency leads to increased oxidative stress, which can lead to cancer. It also indicates that high levels of glutathione have increased antioxidant levels and resistance to oxidative stress in cancer cells.
3. Improves insulin sensitivity and diabetes
Insulin resistance occurs when muscle, fat and liver cells react badly to insulin and cannot use blood glucose for energy. To compensate for this, the pancreas releases more insulin. Over time, blood sugar levels rise because insulin is not enough to transport glucose from the blood to the cells that use it for energy. This can lead to type 2 diabetes.
A small study conducted in 2018 showed that people with insulin resistance tend to have lower glutathione levels, especially if they have had complications such as neuropathy or retinopathy. The 2013 study confirmed this.
As you will see below, our body produces less glutathione with age. Researchers at Baylor Medical School used a combination of animal and human studies to investigate the role of glutathione in weight management and insulin resistance in the elderly. They found that a low glutathione value was associated with a lower value of burned fat and a higher value of body fat. Older subjects were added to the diet with cysteine and glycine (two amino acids) to increase glutathione levels, which increased over a two-week period, improving insulin resistance and fat burning.
Prolonged hyperglycemia is associated with a reduction in glutathione, leading to oxidative stress and tissue damage. A study published in the Diabetes Journal found that dietary supplements containing cysteine and glycine increased glutathione levels. It has also reduced oxidative stress and damage in people with uncontrolled diabetes, despite its high sugar content.
4. Reduces cell damage from alcoholic and non-alcoholic fatty liver disease
Cell death in the liver can be exacerbated by a lack of antioxidants, including glutathione. This can lead to fatty liver disease in both alcoholics and non-drinkers. Hepatitis, alcohol abuse and fatty liver disease are harmful to liver cells.
A small clinical study conducted in 2017 concluded that glutathione may help in the treatment of non-alcoholic fatty liver diseases because of its antioxidant properties and detoxification potential.
The researchers note that larger studies are needed to confirm this effect.
Glutathione has been shown to improve protein, enzyme and bilirubin levels in people with chronic alcoholic and non-alcoholic fatty liver disease.
Another study from 2017 showed that oral administration of glutathione had a positive effect in people with non-alcoholic fatty liver disease after a proactive lifestyle change. In this case, glutathione was administered as an additive at a dose of 300 milligrams per day for four months.
As early as 1995, a study showed that glutathione was more effective in people who had received a high dose of liver fat by intravenous injection. Study participants also showed a decrease in malondialdehyde, a marker of liver cell damage. As you will learn below, the liposomal form of glutathione is as effective as intravenous administration.
5. Increases mobility of people with peripheral vascular disease
Peripheral vascular disease occurs when the peripheral arteries are blocked by plaque. It’s mostly in the legs. In one study the participants were divided into two groups: those who received glutathione and those who received a placebo twice a day for five days. Their mobility was then assessed. As a result, the glutathione group improved blood circulation and was able to walk longer distances without pain than before the introduction of glutathione.
Sign up today for our monthlyLife newsletter.
Discover the latest news, research and health tips that will help you live better and longer.
Sign up today for our monthlyLife newsletter.
Discover the latest news, research and health tips that will help you live better and longer.
6. Reduces symptoms of Parkinson’s disease
Parkinson’s disease affects the central nervous system and is determined by symptoms such as tremor. He doesn’t have a cure yet. A 2002 study documented the positive effects of intravenous glutathione on symptoms such as tremor and stiffness. Although more research is needed, this case shows that glutathione can help reduce symptoms and improve the quality of life of people with Parkinson’s disease.
7. May contribute to the fight against autoimmune diseases.
Chronic inflammations caused by autoimmune diseases can increase oxidative stress. These diseases include rheumatoid arthritis, celiac disease and lupus. According to a 2009 study, glutathione helped reduce oxidative stress by stimulating or reducing the body’s immune response. Autoimmune diseases attack the mitochondria of certain cells. Glutathione works to protect cellular mitochondria by reducing free radicals.
Unfortunately, glutathione decomposes at the age ofyears.
As the graph above shows, the amount of glutathione produced by our body decreases rapidly from the age of 30. At the same time, and partly due to the reduced protection of glutathione, the oxidative stress we experience increases as glutathione levels decrease. Shortly after the age of 60, oxidative stress levels are higher than glutathione levels.
This reduction in glutathione occurs naturally when it is not supported by additives, but various lifestyle factors can reduce it more quickly, for example:
- Poor nutrition
- Alcohol consumption
- Too little movement or too much tension.
- A system overloaded with toxic substances such as heavy metals and pesticides.
- Drugs like Tylenol
- Chronic ignition
- Chronic diseases such as diabetes mellitus, autoimmune diseases and infections.
To avoid reaching the red line in the graph above, where glutathione levels begin to decrease after the age of 30, the addition of liposomal glutathione should be considered.
Why your glutathione should be liposomal glutathione
Of the four glutathione supplements offered by Prohealth Longevity, three are based on liposuction. (The other one is a special form of glutathione called S-acetyl glutathione, which I’ll talk about later).
Liposomes are monolayer and multilayer spheres of phospholipids (basic elements of cell membranes) of microscopic size. Phospholipids include a compound, such as glutathione, to bypass the digestive processes that normally break down the compound or limit its absorption.
(To learn more about phospholipids, 7 Benefits of phosphatidylcholine that can improve your long-term health) .
Liposomes demonstrate the ability to overcome the blood-brain barrier, deposit their charge, such as glutathione, into cells and improve the lymphatic circulation of therapeutic agents. In addition, the phospholipids that make up the liposome fuse with the cell membranes and feed them. 
It is impressive that liposomes can bring the power of intravenous therapy into the comfortable oral cavity. Be aware, however, that not all liposomes are produced in the same way. Most commercially available liposomes use low-quality phospholipids, such as crude lecithin, instead of phospholipid mixtures with a high phosphatidylcholine content, which are necessary for a good liposome. Replenishment manufacturers also generally use low-cost shear methods to produce large (200-600 nm), poorly absorbable particles. 
To provide you with the best liposomal supply of glutathione that your body can quickly absorb, we offer two Quicksilver glutathione supplements and one of our own – all with advanced liposomal technology.
That’s what Dr. Christopher Shay had to say about the power of liposomal administration:
Liposomal glutathione with Quicksilver Scientific sunflower phospholipids offers the power of intravenous therapy in a comfortable oral cavity. Etheric Delivery™ enhances liposome technology with smaller, more stable monolayer spheres made from high quality ingredients.
In addition to their exceptional rate of absorption, nanophores such as Quicksilver have demonstrated their ability to overcome the blood-brain barrier, deposit an intracellular charge and penetrate lymphatic circulation. In addition, phospholipids, which are part of the liposome house, feed the cell membranes. This allows nutrients to be absorbed and cellular wastes and toxins to be released.
Quicksilver’s Liposomal Glutathione Complex adds a powerful blend of milk thistle (supports the liver), B vitamins (promotes metabolism and energy) and other compounds to make it a primary detoxifying substance.
Quicksilver’s two glutathione additives improve the basic technology of liposomal delivery by making smaller, more stable and denser monolayer vesicles (called nylamellar vesicles) from high-quality ingredients. These small blisters begin to absorb as soon as they enter the mouth, allowing high absorption before they are altered by rigid processes in the intestine.
Finally, our third line of liposomal glutathionic acid is ProHealth’s own product, simply called liposomal glutathionic acid. As with Quicksilver’s glutathione products, ProHealth optimizes the size of the liposome spheres for absorption, from 50 to 400 nanometers, and uses natural, non-hydrogenated sunflowers instead of lecithin (which, incidentally, is more of a description of the purification than an identification of the material, as all natural phosphatidylcholine is classified as lecithin).
S-acetyl glutathione for viruses and rapid growth
(Credit: Glutathione pathway.com)
The latest addition to glutathione offered by ProHealth is the improved S-acetyl glutathione Emothion®. I’ll do that in a minute, but first some background on this other form of glutathione.
S-acetyl glutathione is a form of glutathione that optimizes absorption, bioavailability and antiviral properties, for example to combat type 1 herpes simplex (HSV-1).
This glutathione acetylated form occurs when an acetyl group in a glutathione molecule is bound to a cysteine (amino acid) sulfur atom. To understand what an acetyl group is, it is necessary to pass a few chemical tests, but it suffices to say that when it is bound to cysteine, the molecule is protected against oxidation in the gastrointestinal tract and there is no unwanted smell or taste of sulfur atoms.
S-acetyl glutathione is ideal for oral administration because this acetyl group protects glutathione from gastrointestinal damage; after absorption and in the cells it is eliminated, leaving the glutathione molecule intact.
S-acetyl glutathione is also ideal for viral diseases and for more intensive therapy when higher doses are recommended. Not only has it been shown to be stable in the gastrointestinal tract, but it also has a longer plasma half-life with a better ability to penetrate cells and increase intercellular glutathione levels more effectively.  
One study demonstrated the advantage of S-acetyl glutathione over (non-liposomal) glutathione in increasing intracellular glutathione levels, both in vivo (whole living organism) and in vitro (outside a living organism, in a test tube or petri dish). According to this study, a viral infection in cell culture resulted in a significant decrease in intracellular glutathione levels. S-acetyl glutathione restores intracellular glutathione in an effective and dosable way.
The conclusion was that S-acetyl glutathione complements glutathione levels in the body more effectively than regular glutathione supplements and therefore prefers glutathione supplements when a person needs to quickly increase glutathione levels and when higher doses may be desirable.
The same study showed that S-acetylglutathione has antiviral properties when used in cellular and animal models of herpes simplex type 1 (HSV-1) infection by inhibiting viral replication and improving survival better than ordinary glutathione.
ProHealth uses a unique crystalline form of S-acetylglutathione®, called Emothion®, which was developed to overcome the low effectiveness of glutathione additives due to poor absorption and hydrolytic degradation in the body (destroyed in water). Emothion® dissolves quickly and is therefore well absorbed orally.
Which glutathione additive should I choose?
The choice of our glutathione additives naturally depends on your preferences and your budget, but I have some ideas that can help you make your choice:
- If you do not have a specific health problem, i.e. you want to supplement the level of glutathione in your body, you should consider Quicksilver Liposomal Glutathione with Sunflower Phospholipids or ProHealth Liposomal Glutathione.
- If you want to focus on detoxification, look for Quicksilver’s liposomal glutathione complex, as it also contains herbal and detoxifying compounds such as milk thistle and various B vitamins.
- If you suffer from a viral infection or if you want a high and rapid glutathione load, you should consider ProHealth S-Acetyl-Glutathione.
Remember these three things:
- Your body naturally produces glutathione, but as it ages it decreases and eventually the amount is no longer sufficient to combat oxidative stress. (Take another look at this diagram above).
- The only two types of glutathione worth taking are liposomal glutathione and S-acetyl, because both have a high absorption capacity, which is not the case with conventional glutathione.
- Take Quicksilver Liposomal Glutathione with Sunflower Phospholipids or ProHealth Liposomal Glutathione to supplement depleted glutathione; take Quicksilver Liposomal Glutathione Complex to detoxify; and take ProHealth S-acetylglutathione if you have a viral infection or if you want rapid accumulation of glutathione.
glutathione side effects,liposomal glutathione liquid